KN-93 phosphate

KN-93磷酸盐

KN-93 phosphate

K647033-5mg

5mg

≥99%

2-8°C储存,干燥

冰袋运输

KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II , with K i of 370 nM. In Vitro After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CaMK II

KN-93 磷酸酯是一种新型的纯化神经元 CaMK-II 膜渗透合成抑制剂，其 K i 为 370 nM。

1913269-12-1

C26H32ClN2O8PS

599.03 g/mol

16760530

CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC.OP(=O)(O)O

CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC.OP(=O)(O)O

16760530

DMSO : 100 mg/mL (166.94 mM; Need ultrasonic) H2O : 50 mg/mL (83.47 mM; Need ultrasonic)

4

10

11

598.131 Da

598.131 Da

156.000 Ų

39

0

763.000

0

2