K-Ras G12C-IN-4

K-Ras G12C-IN-4

K650604-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRAS G12C. In Vitro K-Ras G12C-IN-4 (4 hours) exhibits IC 50 =0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells. K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC 50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

K-Ras G12C-IN-4（化合物 1）是一种强效的 KRAS G12C 共价抑制剂。

2376328-55-9

C31H33ClN4O4

561.07 g/mol

O=C(NC1CN(C(C=C)=O)C1)CN2C(C3CC3)=C(C(N4CC5=C(C(OC)=CC=C5)CC4)=O)C6=C2C(C)=CC(Cl)=C6

DMSO : 62.5 mg/mL (111.39 mM; ultrasonic and warming and heat to 60°C)