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Levosalbutamol酒石酸盐(levalbuterol)是短效β2肾上腺素受体激动剂salbutamol的R型对映体。 Information Levalbuterol tartrate Levalbuterol HCl is a relatively selective beta2-adrenergic receptor agonist used for the treatment of asthma. In vivo Racemic albuterol (7.5 mg, bid) results in a greater improvement in their forced expiratory volume in 1 second (FEV1) as well as in their asthma scores after 1 hour of continuous treatment compared to the Levalbuterol (3.75 mg, bid) administration in children with asthma. The greater improvement in asthma scores is maintained after the second hour of continuous therapy in the racemic albuterol group but not for forced expiratory volume in 1 second (FEV1) measurements. Levalbuterol (1.25 mg) requires significantly fewer median total nebulizations and scheduled nebulizations compared with those in the racemic albuterol (2.5 mg) group in patients with asthma or chronic obstructive pulmonary disease (COPD). Disease symptom assessment and subject general well-being score scores improves significantly from baseline in both levalbuterol (1.25 mg) and racemic albuterol (2.5 mg) treatment groups, and beta-mediated adverse effects mean scores are significantly greater with levalbuterol versus racemic albuterol.
中文名称
酒石酸左旋布特罗
英文名称
Levalbuterol tartrate
中文别名
-
英文别名
(R)-4-(2-(tert-Butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol (2R,3R)-2,3-dihydroxysuccinate | (R)-4-(2-(tert-Butylamino)-1-hydroxyethyl)-2-(hydroxy-methyl)phenol (2R,3R)-2,3-dihydroxysuccinate | (R)-4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxym
CAS号
661464-94-4
分子式
C30H48N2O12
分子量
628.71 g/mol
精确质量
10mM in DMSO
PSA
-
Logp
-
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左旋沙丁胺醇酒石酸盐(2:1) 99% 100mg

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