Lipofermata

小分子

脂强化菌

Lipofermata

L647455-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

Lipofermata is a fatty acid transport protein 2 (FATP2) inhibitor. Lipofermata shows fatty acid transport inhibition with an IC 50 of 4.84 μM in Caco-2 cells. Lipofermata, an analog of spiro-indoline-thadiazole, shows zinc-specific suppression of antibacterial activity. Lipofermata perturbs zinc homeostasis in E. coli K-12 with a MIC of 16 μM . In Vitro Lipofermata inhibits C1-BODIPY-C12 transport into C2C12, INS-1E, Caco-2 and HepG2 cells at comparable levels yielding sigmoidal dose-response curves with IC 50 s in the low micromolar range (IC 50 =2.74-39.34 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Lipofermata 是一种脂肪酸转运蛋白 2（FATP2）抑制剂。Lipofermata 可抑制脂肪酸转运，在 Caco-2 细胞中的 IC 50 为 4.84 μM。Lipofermata 是螺吲哚啉-噻二唑的类似物，具有锌特异性抗菌抑制作用。

297180-15-5

C15H10BrN3OS

360.2 g/mol

3136622

C1=CC=C(C=C1)C2=NNC3(S2)C4=C(C=CC(=C4)Br)NC3=O

5-bromo-5'-phenylspiro[1H-indole-3,2'-3H-1,3,4-thiadiazole]-2-one

1S/C15H10BrN3OS/c16-10-6-7-12-11(8-10)15(14(20)17-12)19-18-13(21-15)9-4-2-1-3-5-9/h1-8,19H,(H,17,20)

RRBYYBWDUNSVAW-UHFFFAOYSA-N

C1=CC=C(C=C1)C2=NNC3(S2)C4=C(C=CC(=C4)Br)NC3=O

3136622

DMSO : 100 mg/mL (277.60 mM; Need ultrasonic)

2

4

1

358.973 Da

358.973 Da

78.800 Ų

21

0

480

0

1

3.8