L-778123 hydrochloride

小分子

L-778123盐酸盐 | 4-((5-((4-(3-氯苯基)-3-氧代哌嗪-1-基)甲基)-1H-咪唑-1-基)甲酯)苯甲腈盐酸盐

FT-0700272 | 4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile hydrochloride | L-778,123 hydrochloride | Benzonitrile, 4-((5-((4-(3-chlorophenyl)-3-oxo-1-piperazinyl)methyl)-1H-imidazol-1-yl)methyl)-, monohydrochl

L-778123 hydrochloride

L650426-5mg

5mg

Moligand™

≥98%

2-8°C储存,干燥

冰袋运输

对湿度敏感

L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.IC50 value: 2 nM Target: FPTasein vitro: L-778123 can completely inhibit Ki-Ras prenylation.L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent.in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylatedRap1A in PBMCs. Form:Solid

L-778123 hydrochloride 是 FPTase 和 GGPTase-I 的抑制剂，在酶抑制测定中 IC50 值为 2 nM 和 98 nM：体外L-778123可以完全抑制Ki-Ras的前酰化。

253863-00-2

C22H21Cl2N5O

442.34 g/mol

216453

C1CN(C(=O)CN1CC2=CN=CN2CC3=CC=C(C=C3)C#N)C4=CC(=CC=C4)Cl.Cl

4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile;hydrochloride

1S/C22H20ClN5O.ClH/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18;/h1-7,10,12,16H,8-9,13-15H2;1H

YNBSQYGTJLIPJS-UHFFFAOYSA-N

C1CN(C(=O)CN1CC2=CN=CN2CC3=CC=C(C=C3)C#N)C4=CC(=CC=C4)Cl.Cl

216453

253863-00-2

L 778,123;L-778,123;L778123

DMSO : ≥ 25 mg/mL (56.52 mM) H2O : 25 mg/mL (56.52 mM; Need ultrasonic)

1

4

5

441.112 Da

441.112 Da

65.200 Ų

30

0

614.000

0

2