Lotilaner

小分子

洛蒂拉纳

Lotilaner

L651016-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

Lotilaner is a parasiticide , acts as a potent non-competitive antagonist of insects GABACl receptors , with an IC 50 of 23.84 nM for Drosophila melanogaster GABA receptor . No effect on a dog GABAA receptor In Vitro Lotilaner shows IC 50 s of 38.25 ± 3.75, 52.40 ± 4.54, 36.79 ± 4.39 nM for Drosophila melanogaster dieldrin/fipronil-resistant forms (DmR2), Lepeophtheirus salmonis (Ls) and Rhipicephalus microplus (Rm) GABACl receptors, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 23.84 nM (DmS-GABA), 38.25 nM (DmR2-GABA), 52.40 nM (Ls-GABA1), 36.79 nM (Rm-GABA)

Lotilaner 是一种杀寄生虫药，是昆虫 GABACl 受体的强效非竞争性拮抗剂，对黑腹果蝇 GABA 受体的 IC 50 为 23.84 nM。对狗的 GABAA 受体无影响。

1369852-71-0

C20H14Cl3F6N3O3S

596.76 g/mol

76959255

CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F

CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F

76959255

DMSO : ≥ 100 mg/mL (167.57 mM)

2

11

6

594.973 Da

594.973 Da

108.000 Ų

36

0

868.000

0

1

6.600