LY3154207

小分子

4A3702A96F | 1638667-79-4 | A-5440 | AKOS040733644 | compound 3 [PMID: 31532644] | GTPL10506 | Q410712 | UNII-4A3702A96F | XHCSBQBBGNQINS-DOTOQJQBSA-N | AT24876 | Ethanone, 2-(2,6-dichlorophenyl)-1-((1S,3R)-3,4-dihydro-3-(hydroxymethyl)-5-(3-hydroxy-3-met

LY3154207

L651647-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity ( EC 50 =3 nM) In Vitro In HEK293 cells transiently expressing human, dog, rhesus monkey, and mouse D1 receptors, the EC 50 s of LY3154207 are 2.3 nM, 2.0 nM, 2.5 nM, and 62.1 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EC50: 3 nM (human dopamine D1 receptor)

LY3154207 是一种强效的亚型选择性口服人多巴胺 D1 受体正性异位调节剂（PAM），具有最小异位激动剂活性（EC 50 =3 nM）。

1638667-79-4

C24H29Cl2NO3

450.40 g/mol

86290953

C[C@H]1C2=CC=CC(=C2C[C@@H](N1C(=O)CC3=C(C=CC=C3Cl)Cl)CO)CCC(C)(C)O

2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone

1S/C24H29Cl2NO3/c1-15-18-7-4-6-16(10-11-24(2,3)30)19(18)12-17(14-28)27(15)23(29)13-20-21(25)8-5-9-22(20)26/h4-9,15,17,28,30H,10-14H2,1-3H3/t15-,17+/m0/s1

XHCSBQBBGNQINS-DOTOQJQBSA-N

CC1C2=CC=CC(=C2CC(N1C(=O)CC3=C(C=CC=C3Cl)Cl)CO)CCC(C)(C)O

86290953

1638667-79-4

2-(2,6-Dichlorophenyl)-1-((1 S,3 R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one;LY3154207;Mevidalen

DMSO : 110 mg/mL (244.23 mM; Need ultrasonic)

2

3

6

449.152 Da

449.152 Da

60.800 Ų

30

0

577.000

0

1

4.400

4.4