Larazotide acetate, 神经元乙酰胆碱受体；α3/β4 部分激动剂

醋酸拉唑肽

Larazotide acetate

L654505-1ml

1ml

10mM in Water

干燥,-80℃储存

超低温冰袋运输

Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC 50 s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection . In Vitro Larazotide acetate (1-100 μM; 5 d) affects Vero cell growth. Larazotide acetate (1-100 μM; 3 d) shows antiviral activity to varicella-zoster virus (VZV) with EC 50 s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate (1 and 3 mM; 72 h) inhibits cytokine-induced tight junction permeability in Caco-2 cells. Larazotide acetate (12.5 mM; 1 h) inhibits PTG-induced ZO-1 redistribution and actin cytoskeletal rearrangement in IEC6 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: Vero cell line Concentration: 1-100 μM Incubation Time: 5 days Result: Inhibited Vero cell growth with an CC 50 value of 82.5 μM. In Vivo Larazotide acetate (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: HLA-HCD4/DQ8 double transgenic miceDosage: 250 μg Administration: Intraperitoneal injection; 250 μg twice a week for 7 weeks Result: Improved barrier function parameters and reduced macrophage counts in the lamina propria to control levels. IC50& Target:Paracellular permeability

醋酸拉拉唑肽是一种多肽，是一种口服活性佐宁拮抗剂。醋酸拉拉唑肽对水痘-带状疱疹病毒（VZV）具有抗病毒活性，对 OKA 株和 07-1 株的 EC 50 s 分别为 44.14 和 59.06 μM。醋酸拉拉唑肽可

881851-50-9(Water)

C34H59N9O12

785.89 g/mol

CC(C)CC(C(=O)NC(C(C)C)C(=O)NC(CCC(=O)N)C(=O)N1CCCC1C(=O)NCC(=O)O)NC(=O)C(C(C)C)NC(=O)CNC(=O)CN.CC(=O)O

部分激动剂

神经元乙酰胆碱受体；α3/β4 部分激动剂