L-372662

L-372662

L654535-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

L-372662 is a potent and orally active non-peptide oxytocin antagonist with a K i value of 4.8. The K d value of L-372662 for wild-type hOTR and [A318G]OTR is 5.8 nM and 73 nM. L-372662 shows selectivity to OTR:V 1a R In Vivo L-372662 is an antagonist of oxytocin-induced uterine contractions in late gestation pregnant rhesus monkeys (AD50 = 36 micrograms/kg), oral bioavailability (F = 90% in dogs), and aqueous solubility (10 mg/mL). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Ki: 4.8 (oxytocin)

L-372662 是一种强效的口服活性非肽催产素拮抗剂，其 K i 值为 4.8。L-372662 对野生型 hOTR 和 [A318G]OTR 的 K d 值分别为 5.8 nM 和 73 nM。L-372662 对 OTR:V 1a R 具有选择性。

162045-26-3(DMSO)

C33H38N4O6

586.68 g/mol

CC1=C(C=CC=[N+]1[O-])CN2CCC(CC2)OC3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5C6=CC=CC=C6COC5=O)OC