L-778123 hydrochloride

L-778123盐酸盐

L-778123 hydrochloride

L656264-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.IC50 value: 2 nM Target: FPTasein vitro: L-778123 can completely inhibit Ki-Ras prenylation.L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent.in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylatedRap1A in PBMCs.

L-778123 hydrochloride 是 FPTase 和 GGPTase-I 的抑制剂，在酶抑制测定中 IC50 值为 2 nM 和 98 nM：体外L-778123可以完全抑制Ki-Ras的前酰化。

253863-00-2(DMSO)

C22H21Cl2N5O

442.34 g/mol

C1CN(C(=O)CN1CC2=CN=CN2CC3=CC=C(C=C3)C#N)C4=CC(=CC=C4)Cl.Cl