Lotilaner

洛蒂拉纳

Lotilaner

L656491-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

Lotilaner is a parasiticide , acts as a potent non-competitive antagonist of insects GABACl receptors , with an IC 50 of 23.84 nM for Drosophila melanogaster GABA receptor . No effect on a dog GABAA receptor In Vitro Lotilaner shows IC 50 s of 38.25 ± 3.75, 52.40 ± 4.54, 36.79 ± 4.39 nM for Drosophila melanogaster dieldrin/fipronil-resistant forms (DmR2), Lepeophtheirus salmonis (Ls) and Rhipicephalus microplus (Rm) GABACl receptors, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 23.84 nM (DmS-GABA), 38.25 nM (DmR2-GABA), 52.40 nM (Ls-GABA1), 36.79 nM (Rm-GABA)

Lotilaner 是一种杀寄生虫药，是昆虫 GABACl 受体的强效非竞争性拮抗剂，对黑腹果蝇 GABA 受体的 IC 50 为 23.84 nM。对狗的 GABAA 受体无影响。

1369852-71-0(DMSO)

C20H14Cl3F6N3O3S

596.76 g/mol

O=C(NCC(NCC(F)(F)F)=O)C1=C(C=C(S1)C2=NO[C@](C3=CC(Cl)=C(C(Cl)=C3)Cl)(C2)C(F)(F)F)C