Lesogaberan hydrochloride

盐酸莱索加贝兰

Lesogaberan hydrochloride

L658928-5mg

5mg

≥98%

2-8°C储存,充氩

冰袋运输

Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABA B receptor agonist with an EC 50 of 8.6 nM for human recombinant GABA B receptor. The affinity ( K i s) of Lesogaberan hydrochloride for rat GABA B and GABA A receptors, as measured by di Appearance:Viscous liquid IC50& Target:Ki: 5.1±1.2 nM (rat GABA B ), 1.4±0.3 μM (rat GABA A ) EC50: 8.6±0.77 nM (human GABA B receptor) In Vitro:Lesogaberan hydrochloride (3-30 nM) enhances human islet cell proliferation in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: Human islet cells Concentrat In Vivo:Lesogaberan hydrochloride potently stimulates recombinant human GABA B receptors and inhibits transient lower esophageal sphincter relaxation (TLESR) in dogs, with a biphasic dose-response curve. Oral Lesogaberan (0.08 mg/mL; 48 hours) hydrochloride Biological Activity:Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABA B receptor agonist with an EC 50 of 8.6 nM for human recombinant GABA B receptor. The affinity ( K i s) of Lesogaberan hydrochloride for rat GABA B and GABA A receptors, as measured by di

C3H10ClFNO2P

177.54 g/mol

O=P(C[C@H](F)CN)O.[H]Cl

DMSO : 240 mg/mL (1351.81 mM; Need ultrasonic) H2O : 100 mg/mL (563.25 mM; Need ultrasonic)