L-Moses dihydrochloride

L-摩西二盐酸盐

L-Moses dihydrochloride

L659136-5mg

5mg

2-8°C储存,干燥

冰袋运输

L-Moses (L-45) dihydrochloride is the first potent, selective, and cell-active p300/CBP-associated factor ( PCAF ) bromodomain ( Brd ) inhibitor with a K d of 126 nM. Appearance:Solid IC50& Target:Brd 126 nM (Kd) In Vitro:L-Moses (L-45) disrupts PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co-crystal structure of L-Moses with the homologous Brd Pf GCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. A In Vivo:L-Moses (L-45) shows no observable cytotoxicity in peripheral blood mononuclear cells (PBMC), good cell-permeability, and metabolic stability in human and mouse liver microsomes, supporting its potential for in vivo use. MCE has not independently con Biological Activity:L-Moses (L-45) dihydrochloride is the first potent, selective, and cell-active p300/CBP-associated factor ( PCAF ) bromodomain ( Brd ) inhibitor with a K d of 126 nM.

C21H26Cl2N6

433.38 g/mol

C[C@@H]([C@H](C1=CC=CC=C1)N(C)C)NC(C2=C3C=CC=C2)=NN4C3=NN=C4C.[H]Cl.[H]Cl