亮氨酸氨基肽酶，微粒体 来源于猪肾脏

L755285-25U

25U

Type VI-S, lyophilized powder,≥12 units/mg protein (biuret)

亮氨酸氨肽酶，来自猪肾的微粒体已用于腺癌细胞系ES-2中氨肽酶N（APN）抑制剂的筛选检测以及APN抑制剂的抑制动力学研究中。应用： 来自猪的亮氨酸氨肽酶（LAP）是存在于胞质溶胶中的一种320-kDa外肽酶。它的结构中含有锌，属于M1和M17肽酶家族。LAP具有双叶结构并在C末端具有催化结构域以及一个可变的N末端结构域。 Leucine Aminopeptidase (LAP) from porcine is a 320-kDa exopeptidase present in cytosol. It contains zinc in its structure and belongs to the M1 and M17 peptidase families. LAP display bi-lobed structure and has the catalytic domain at the C-terminus and a variable N-terminal domain. Application: Leucine Aminopeptidase, microsomal from porcine kidney has been used in aminopeptidase N (APN) inhibitor screening assay in adenocarcinoma cell line ES-2 and in the inhibition kinetic studies with APN inhibitor.

亮氨酸氨肽酶（LAP）可在N-末端的亮氨酸残基处催化蛋白的水解。 LAP水平的改变与肿瘤的增殖和进展有关。LAP是卵巢上皮癌治疗的一种潜在生物标志物。 猪LAP可水解甘氨酸和精氨酸底物。