L-α-Aminoadipic acid, a gliotoxic analogue of glutamate, has been shown to competitively inhibit the transport protein of D-[3H]-aspartate. Experiments have reported that this compound also causes a reduction in ischemic glutamate release in murine hippocampal slices in vitro. Additional research suggests that L-α-Aminoadipic acid inhibits astrocyte culture Kynurenic acid synthesis which demonstrates the ability to modulate neuronal degeneration. L-α-Aminoadipic acid is a inhibitor of GluR and Gl Syn. An inhibitor of ischemic glutamate release