M40 is a potent, non-selective galanin receptor antagonist. In Vitro M40 (1 μM) displaces [mono[ 125 IJodo-Tyr 26 ]galanin from binding sites in the hippocampus, hypothalamus, and spinal cord. M40 has a lower affinity than galanin for all membranes. The IC 50 values are 6 nM in the hippocampus, 15 nM in the hypothalamus, 12 nM in the spinal cord, and 3 nM in the insulinoma cells. M40 (1 μM) completely blocks 125 I-labeled galanin-binding sites. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid