莫纳霉素是从1963年首次报道的数种链霉菌属中分离出来的大环多元醇内酯。莫纳霉素对革兰氏阳性细菌具有活性，而革兰氏阴性活性较弱。在溶液中，莫那霉素以亲水簇的形式存在，当吸附到脂质双层上时，可以诱导通道形成。莫那霉素是了解膜通道的重要生物探针。 Monazomycin is a macrocylic polyol lactone isolated from several species of|Streptoverticillium|, first reported in 1963. Monazomycin is active against Gram positive bacteria with weak Gram negative activity. In solution, monazomycin exists as hydrophilic clusters which, when adsorbed onto a lipid bilayer, can induce channel formation. Monazomycin is an important bioprobe for understanding membrane channels.