MeOSuc-AAPV-pNA，发色底物

N-甲氧基琥珀酰-Ala-Ala-Pro-Val 对硝基苯胺 | N-（甲氧基琥珀酰基）-L-丙氨酰-L-丙氨酰-L-脯氨酰-L-缬氨酸4-硝基苯胺 | N-（甲氧基琥珀酰基）-Ala-Ala-Pro-Val 4-硝基苯胺

MeOSuc-Ala-Ala-Pro-Val-PNA | N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide

M331874-10mg

10mg

Moligand™

≥98%

分子式: C 27 H 38 N 6 O 9 分子量: 590.63 MeOSuc-AAPV-pNA，生色底物是PR3（蛋白酶3； PRTN3）和中性粒细胞弹性蛋白酶的敏感生色底物。PR3是一种多形核白细胞（PMNL）丝氨酸蛋白酶，可降解多种基质蛋白，包括纤连蛋白，层粘连蛋白，玻连蛋白和IV型胶原，并有助于蛋白水解生成抗菌肽。中性粒细胞弹性蛋白酶是一种丝氨酸蛋白酶，在炎症过程中被中性粒细胞分泌，破坏细菌和宿主组织。评估人和鼠的PR3和中性粒细胞弹性蛋白酶有助于了解PR3相关的炎症性自身免疫过程。研究人员已将该产品用于囊性纤维化研究，因为据报道，弹性蛋白的降解在囊性纤维化患者 MeOSuc-AAPV-pNA, Chromogenic Substrate is a sensitive chromogenic substrate for PR3 (proteinase 3; PRTN3) and neutrophil elastase. PR3 is a polymorphonuclear leukocyte (PMNL) serine proteinase that degrades a variety of matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV and contributes to the proteolytic generation of antimicrobial peptides. Neutrophil elastase is a serine proteinase that during inflammation, is secreted by neutrophils to destroy bacteria as well as host tissue. Evaluating human and murine PR3 and neutrophil elastase enzymes are helpful to understanding PR3-related and inflammatory autoimmune processes. Researchers have used this product in cystic fibrosis research, as elastin degradation has been reported to increase in cystic fibrosis patients. Hydrolysis or cleavage of this substrate product can be detected at 405-410 nm. This product is not a suitable substrate for cathepsin G nor chymotrypsin.

MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive chromogenic substrate for human leukocyte and porcine pancreatic elasta.

6266359

N-Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide