Information MLT-748 MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state. Targets MALT1 (Cell-free assay) 5 nM In vitro MLT-748 binds MALT1 in the allosteric Trp580 pocket. MLT-748 binds and stabilizes mutant MALT1-W580S. Cleavage of MALT1 substrates is blocked by MLT-748 in B and T cells. MLT-748 rescues MALT1 function in patient MALT1 mut/mut lymphocytes. Cell Research(from reference) Cell lines：Immortalized B cells, human PBMCs, primary human CD3+ T cells, primary CD4+ lymphocytes Concentrations：2 μM Incubation Time：24 h