MDL-28170 (Calpain Inhibitor III) 是一种有效的、选择性的、具有膜渗透性的半胱氨酸蛋白酶 (calpain)抑制剂，可在全身给药后迅速穿过血脑屏障。MDL-28170 还能阻断γ-secretase。 application： MDL 28170 has been used as a calpain inhibitor: to study its effects on neuroinflammation and necroptosis in rat model of cardiac arrest to analyze its effects on the degradation of neuronal nitric oxide synthase (nNOS) in beef semimembranosus muscle to study its protective effects against traumatic brain injury and survival of bone marrow-derived mesenchymal stem cells (BMSCs) in rat brain；