ML148

小分子

ML148

M647091-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

ML148 is a potent and selective 15-PGDH inhibitor with an IC 50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways In Vitro ML148 (compound 13) shows selectivity with IC 50 s of 56, 36000, >57500, >57500 nM for 15-PGDH, ALDH1A1, HADH2, HSD17β4, respectively. ML148 (10, 20 nM) decrease V max by 25% and reduces the apparent K m by half at a concentration of 10 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC 50 : 56 nM (15-PGDH)

ML148 是一种强效的选择性 15-PGDH 抑制剂，其 IC 50 为 56 nM。ML148 具有研究前列腺素信号通路的潜力。

451496-96-1

C20H21N3O

319.4 g/mol

3243760

CC1=CC(=CC=C1)N2C=NC3=C2C=CC(=C3)C(=O)N4CCCCC4

[1-(3-methylphenyl)benzimidazol-5-yl]-piperidin-1-ylmethanone

1S/C20H21N3O/c1-15-6-5-7-17(12-15)23-14-21-18-13-16(8-9-19(18)23)20(24)22-10-3-2-4-11-22/h5-9,12-14H,2-4,10-11H2,1H3

YQNOQZALLOQMPY-UHFFFAOYSA-N

CC1=CC(=CC=C1)N2C=NC3=C2C=CC(=C3)C(=O)N4CCCCC4

3243760

DMSO : 50 mg/mL (156.54 mM; ultrasonic and warming and heat to 80°C)

0

2

2

319.168 Da

319.168 Da

38.100 Ų

24

0

448.000

0

1

3.800