Mardepodect hydrochloride

盐酸马德普特

2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline;hydrochloride | PF-2545920 (hydrochloride) | MS-27603 | Quinoline, 2-((4-(1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl)phenoxy)methyl)-, hydrochloride (1:1) | LTZ83KS2UW | Mardepodect hydroch

Mardepodect hydrochloride

M649719-5mg

5mg

≥95%

2-8°C储存,干燥

冰袋运输

Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC 50 of 0.37 nM, with >1000-fold selectivity over other PDEs . Mardepodect hydrochloride can cross the blood-brain barrier In Vivo In the conditioned avoidance response assay (CAR), Mardepodect (PF-2545920) is active with an ED 50 of 1 mg/kg. Administration of Mardepodect (PF-2545920) to mice causes a dose dependent increase in striatal cGMP. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.37 nM (PDE10A)

Mardepodect hydrochloride（PF-2545920 盐酸盐）是一种强效、具有口服活性和选择性的 PDE10A 抑制剂，其 IC 50 为 0.37 nM，与其他 PDE 相比，选择性大于 1000 倍。Mardepodect 盐酸盐可透过血脑屏障。

2070014-78-5

C25H21ClN4O

428.91 g/mol

122412737

CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)C5=CC=NC=C5.Cl

2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline;hydrochloride

1S/C25H20N4O.ClH/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21;/h2-16H,17H2,1H3;1H

BDHTXAXWOXYUDG-UHFFFAOYSA-N

CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)C5=CC=NC=C5.Cl

122412737

2070014-78-5

DMSO : 25 mg/mL (58.29 mM; Need ultrasonic)

1

4

5

428.14 Da

428.14 Da

52.800 Ų

31

0

531

0

2