Mizacorat

小分子

米萨科拉特

AZD 9567 [WHO-DD] | HY-120012 | US10196374, Example 1 | 1893415-00-3 | example 1 [WO2016046260A1] | BDBM332659 | SCHEMBL17643955 | EX-A7251 | B9W | Q29213655 | 2,2-difluoro-N-[(1R,2S)-3-methyl-1-[1-(1-methyl-6-oxopyridin-3-yl)indazol-5-yl]oxy-1-phenylbuta

Mizacorat

M650053-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM) , with an IC 50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation In Vivo Mizacorat (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW . Dosage: 15 mg/kg/day. Administration: Oral gavage daily for 8 days. Result: Inhibited ankle swelling in the rat SCW model. Form:Solid IC50& Target:IC50: 3.8 nM (Glucocorticoid receptor)

Mizacorat（AZD9567；化合物 15）是一种强效的口服活性非甾体选择性糖皮质激素受体调节剂（SGRM），IC 50 为 3.8 nM。在链球菌细胞壁（SCW）再活化关节炎模型中表现出卓越的疗效

1893415-00-3

C27H28F2N4O3

494.53 g/mol

121248172

CC(C)[C@@H]([C@@H](C1=CC=CC=C1)OC2=CC3=C(C=C2)N(N=C3)C4=CN(C(=O)C=C4)C)NC(=O)C(C)(F)F

2,2-difluoro-N-[(1R,2S)-3-methyl-1-[1-(1-methyl-6-oxopyridin-3-yl)indazol-5-yl]oxy-1-phenylbutan-2-yl]propanamide

1S/C27H28F2N4O3/c1-17(2)24(31-26(35)27(3,28)29)25(18-8-6-5-7-9-18)36-21-11-12-22-19(14-21)15-30-33(22)20-10-13-23(34)32(4)16-20/h5-17,24-25H,1-4H3,(H,31,35)/t24-,25+/m0/s1

ZQFNDBISEYQVRR-LOSJGSFVSA-N

CC(C)C(C(C1=CC=CC=C1)OC2=CC3=C(C=C2)N(N=C3)C4=CN(C(=O)C=C4)C)NC(=O)C(C)(F)F

121248172

1893415-00-3

AZD-9567;AZD9567

DMSO : 100 mg/mL (202.21 mM; Need ultrasonic) H2O : 0.67 mg/mL (1.35 mM; Need ultrasonic)

1

6

8

494.213 Da

494.213 Da

76.500 Ų

36

0

871.000

0

1

4.700