Mefentrifluconazole

氟康唑

Mefentrifluconazole

M651053-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent . Mefentrifluconazole is a potent, selective and orally active fungal CYP51 ( K d = 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase ( IC 50 =0.92 μM) In Vivo Mefentrifluconazole undergoes extensive toxicity testing, including a full program of reproductive toxicity studies. Long term repeated dose toxicity and/or carcinogenicity studies have been conducted in rats, mice, and dogs. In each species, the highest dose level investigated gives rise to systemic toxicity . In the acute and?repeat dose toxicity studies?performed with Mefentrifluconazole. A single-dose administration to rats the LD50 is >2000?mg/kg bwt by the oral route, >5000?mg/kg bwt by the dermal route, and >5.314?mg/L by inhalation as a dust aerosol. Mefentrifluconazole is not a skin or an eye?irritant, nor is it a phototoxicant in vitro . In the acute?neurotoxicity?study in rats, Mefentrifluconazole (oral administration; 2000?mg/kg bwt; single dose) gives rise to reduce body weight gain and transient neurobehavioral effects only on the day of treatment (unsteady gait, reduced motor activity, reduces grip strength of the forelimbs and increased distance between the hind limbs in the landing foot-splay test) . In the repeated-dose toxicity studies, the liver is the target organ in each of the three species investigated. At higher dose levels in the rat (oral diets; 383/334 mg/kg/bwt/d (4000 ppm)) and the C57BL/6JRj mouse (61 mg/kg bwt/d (300 ppm)), reduces body weight gain and food consumption, alters clinical chemistry parameters, increases liver weight and is accompanied by?liver cell hypertrophy, and/or?liver cell necrosis. At low doses, increases liver weight is not associated with any histopathological alterations and is considered to be an adaptive change to treatment . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CYP51A 0.5 nM (Kd)

Mefentrifluconazole 是一种新型唑类衍生物，用作农用化学品广谱抗真菌剂。Mefentrifluconazole 是一种强效、具有选择性和口服活性的真菌 CYP51（K d = 0.5 nM）抑制剂，但对人体的抑制活性较低。

1417782-03-6

C18H15ClF3N3O2

397.78 g/mol

71230671

CC(CN1C=NC=N1)(C2=C(C=C(C=C2)OC3=CC=C(C=C3)Cl)C(F)(F)F)O

CC(CN1C=NC=N1)(C2=C(C=C(C=C2)OC3=CC=C(C=C3)Cl)C(F)(F)F)O

71230671

DMSO : 100 mg/mL (251.40 mM; Need ultrasonic)

1

7

5

397.08 Da

397.08 Da

60.200 Ų

27

0

491

0

1

4