ML-109

小分子

AC-36479 | AKOS037648530 | ML 109; ML109 | NCGC00161870-01 | CHEBI:91942 | D81075 | MFCD31746908 | Q27163740 | BS-14451 | N-[4-[[5-[5-hydroxy-4-oxo-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]-2-methoxyphenyl]methoxy]phenyl]acetamide | N-[4-[[5-(3-benzyl-

ML-109

M651343-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC 50 of 40 nM. In Vitro ML-109 (Compound 2) is a full agonist at TSHR with an EC 50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t 1/2 of ~16 h) but is found to degrade at low pH (t 1/2 of ~3 h). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EC50: 40 nM (TSHR)

ML-109 是一种强效、全面的促甲状腺激素受体（TSHR）激动剂，EC 50 为 40 nM。

1186649-91-1

C31H29N3O5

523.58 g/mol

25246343

CC(=O)NC1=CC=C(C=C1)OCC2=C(C=CC(=C2)C3NC4=C(C(=CC=C4)O)C(=O)N3CC5=CC=CC=C5)OC

N-[4-[[5-(3-benzyl-5-hydroxy-4-oxo-1,2-dihydroquinazolin-2-yl)-2-methoxyphenyl]methoxy]phenyl]acetamide

1S/C31H29N3O5/c1-20(35)32-24-12-14-25(15-13-24)39-19-23-17-22(11-16-28(23)38-2)30-33-26-9-6-10-27(36)29(26)31(37)34(30)18-21-7-4-3-5-8-21/h3-17,30,33,36H,18-19H2,1-2H3,(H,32,35)

JRVXFGNCHKHBPA-UHFFFAOYSA-N

CC(=O)NC1=CC=C(C=C1)OCC2=C(C=CC(=C2)C3NC4=C(C(=CC=C4)O)C(=O)N3CC5=CC=CC=C5)OC

25246343

1186649-91-1

DMSO : 83.33 mg/mL (159.15 mM; Need ultrasonic)

3

6

8

523.211 Da

523.211 Da

100.000 Ų

39

0

812

0

1

5.1