Mutant IDH1-IN-2

小分子

突变型IDH1-IN-2

Mutant IDH1-IN-2

M651439-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.Target: Mutant IDH1 Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer . More bioactivity information in Patent WO 2013046136A1 (Example 224). Form:Solid

Mutant IDH1-IN-2 是突变型异柠檬酸脱氢酶（IDH）蛋白的抑制剂，在 LS-MS 生化检测中的 IC50 为 16.6 nM，在荧光生化检测中的 IC50 为 16.6 nM：突变体 IDH1 突变体 IDH1-IN-2 具有新变态活性，在治疗突变体 IDH1 和 IDH1-IN-2 的过程中，其活性与突变体 IDH1 和 IDH1-IN-2 的活性相同。

1429176-69-1

C24H31F2N5O2

459.53 g/mol

O=C1OC[C@H](C(C)C)N1C2=NC(N[C@H](C3=CC=C(CN4CCC(F)(F)CC4)C=C3)C)=NC=C2

DMSO : 50 mg/mL (108.81 mM; Need ultrasonic)