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MP7 (PDK1 inhibitor) is a phosphoinositide-dependent kinase-1 ( PDK1 ) inhibitor. In Vitro Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 (PDK1 inhibitor) are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment, MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation. MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines, with IC 50 values in the micromolar range. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PDK1
中文名称
MP7
英文名称
MP7
中文别名
-
英文别名
DTXSID90678515 | 1-(3,4-Difluorobenzyl)-2-Oxo-N-{(1r)-2-[(2-Oxo-2,3-Dihydro-1h-Benzimidazol-5-Yl)oxy]-1-Phenylethyl}-1,2-Dihydropyridine-3-Carboxamide | BRD-K09186807-001-01-6 | CHEBI:91373 | HY-14440 | PDK1 inhibitor | BDBM50361645 | NCGC00346947-02 | SC
CAS号
1001409-50-2
分子式
C28H22F2N4O4
分子量
516.50 g/mol
精确质量
≥99%
PSA
99.800 Ų
Logp
4
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MP7 5mg

品牌:阿拉丁
货号:M651716-5mg
级别: ≥99%
货期:30天
已售 863 件
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