MI-773

小分子

MI-773

M654852-1ml

1ml

10mM in DMSO

充氩,-80℃储存

超低温冰袋运输

MI-773 is a potent MDM2-p53 protein‐protein interaction (PPI) inhibitor with high binding affinity against MDM2 (K d =8.2 nM). MI-773 has antitumor activity. In Vitro SAR405838 (MI-77301), an analog of MI-773, displays 10 times higher binding affinity against MDM2 than MI-773 (K d =62 vs 8.2 nM). The antitumor activity of MI-77301 is more pronounced in a set of wild type p53 xenograft models than MI-773, including SJSA-1 osteosarcoma, human prostate, melanoma, colorectal tumor, LNCAP human prostate tumor and human acute lymphoblastic leukemia. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MI-773 是一种强效的 MDM2-p53 蛋白-蛋白相互作用（PPI）抑制剂，与 MDM2 的结合亲和力很高（K d =8.2 nM）。MI-773 具有抗肿瘤活性。

1303607-07-9(DMSO)

C29H34Cl2FN3O3

562.5 g/mol

CC(C)(C)CC1C2(C(C(N1)C(=O)NC3CCC(CC3)O)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O

32303642