Mogrol

莫格罗尔

Mogrol

M655097-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling. In Vitro Mogrol (0-250 µM) significantly and dose- and time-dependently inhibits K562 cell growth and increases the number of apoptotic cells. Mogrol (0, 10, 100, and 250 µM) induces G1 phase cell cycle arrest in K562 cells. Treatment with mogrol significantly decreases ERK phosphorylation as compared to control cells, whereas total ERK protein is not affected. Mogrol dose-dependently induces growth arrest in G0/G1 phase of the cell cycle. Mogrol significantly and dose-dependently enhances p21 protein expression in K562 cells. Mogrol significantly represses the increase in cellular TG levels induced by differentiation stimuli, and suppresses TG accumulation at micromolar levels, with a statistically significant suppression observed above 10 μM. Mogrol suppresses adipogenesis in 3T3-L1 cells at concentrations that does not affect cell viability. Mogrol suppresses adipogenesis through at least two different mechanisms, increasing AMPK phosphorylation and repressing the activation of CREB. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:ERK1 ERK2 STAT3

莫格罗尔是莫格罗苷的生物代谢产物，通过抑制 ERK1/2 和 STAT3 途径或减少 CREB 激活和激活 AMPK 信号发挥作用。

88930-15-8(DMSO)

C30H52O4

476.73 g/mol

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