Mardepodect hydrochloride

盐酸马德普特

Mardepodect hydrochloride

M655967-1ml

1ml

10mM in DMSO

干燥,-80℃储存

超低温冰袋运输

Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC 50 of 0.37 nM, with >1000-fold selectivity over other PDEs . Mardepodect hydrochloride can cross the blood-brain barrier In Vivo In the conditioned avoidance response assay (CAR), Mardepodect (PF-2545920) is active with an ED 50 of 1 mg/kg. Administration of Mardepodect (PF-2545920) to mice causes a dose dependent increase in striatal cGMP. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 0.37 nM (PDE10A)

Mardepodect hydrochloride（PF-2545920 盐酸盐）是一种强效、具有口服活性和选择性的 PDE10A 抑制剂，其 IC 50 为 0.37 nM，与其他 PDE 相比，选择性大于 1000 倍。Mardepodect 盐酸盐可透过血脑屏障。

2070014-78-5(DMSO)

C25H21ClN4O

428.91 g/mol

CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)C5=CC=NC=C5.Cl