MS645

MS645

M656887-1ml

1ml

10mM in DMSO

充氩,-80℃储存

超低温冰袋运输

MS645 is a bivalent BET bromodomains (BrD) inhibitor with a K i of 18.4 nM for BRD4-BD1/BD2. MS645 spatially constrains bivalent inhibition of BRD4 BrDs resulting in a sustained repression of BRD4 transcriptional activity in solid-tumor cells In Vitro MS645 has cell growth inhibitory effects on noncancer cell lines of mouse macrophage RAW cells and nontumorigenic breast epithelial MCF10A with IC 50 s of 4.1 nM, 6.8 nM, 7.9 nM for triple-negative breast cancer (TNBC) cell lines HS5878T, BT549, and MCF 10A. ?\nMS645 (15, 30, 60 nM) results in a dramatic reduction of c-Myc expression and an increase of p21, a tumor suppressor and cell-cycle inhibitor in HCC1806 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:BRD4(BD1BD2) 18.4 nM (Ki)

MS645 是一种双价 BET 溴odomains (BrD) 抑制剂，对 BRD4-BD1/BD2 的 K i 为 18.4 nM。MS645 在空间上限制了对 BRD4 BrDs 的二价抑制，从而持续抑制了实体瘤细胞中 BRD4 的转录活性。

2250091-96-2(DMSO)

C48H54Cl2N10O2S2

938.04 g/mol

CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCCCCCCCCCNC(=O)CC4C5=NN=C(N5C6=C(C(=C(S6)C)C)C(=N4)C7=CC=C(C=C7)Cl)C)C8=CC=C(C=C8)Cl)C