MMAF-d8hydrochloride

MMAF-d8盐酸盐

MMAF-d8hydrochloride

M658677-1mg

1mg

≥99%

2-8°C储存,干燥

冰袋运输

MMAF-d 8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent. Appearance:Solid IC50& Target:Auristatin In Vitro:MMAF shows in vitro cytotoxicity against a panel of cell lines. The IC 50 values for Karpas 299, H3396, 786-O and Caki-1 are 119, 105, 257, and 200 nM, respectively. Targeted MMAF is much more potent than the free drug, and that cAC10 conjugates of MMAF d In Vivo:The maximum tolerated dose in mice of MMAF (>16mg/kg) is much higher than MMAE (1mg/kg). cAC10-L1-MMAF 4 has an MTD of 50mg/kg in mice and 15mg/kg in rats. The corresponding cAC10-L4-MMAF 4 ADC was much less toxic, having MTDs in mice and rats of >150 Biological Activity:MMAF-d 8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.

C39H58D8ClN5O8

776.47 g/mol

O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](C)[C@@H](OC)[C@H]2N(C(C[C@@H](OC)[C@@H](N(C)C([C@@]([2H])(NC([C@@H](NC)C(C)C)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)[C@@H](C)CC)=O)CCC2)=O.Cl

DMSO : 100 mg/mL (128.79 mM; Need ultrasonic)