Mps1-IN-3 hydrochloride

Mps1-IN-3 盐酸盐

Mps1-IN-3 hydrochloride

M659081-5mg

5mg

≥98%

-20°C储存,干燥

超低温冰袋运输

Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC 50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma Appearance:Solid IC50& Target:IC 50 : 50 nM (Mps1) In Vitro:Mps1-IN-3 hydrochloride (0.3-10 μM) inhibits the marker of mitotic cells cyclin B in a dose-dependent manner. Mps1-IN-3 hydrochloride (2 μM) causes a dose-dependent escape from a checkpoint-mediated mitotic arrest. Mps1-IN-3 hydrochloride (1-15 In Vivo:Mps1-IN-3 hydrochloride (2mg/kg; IV, twice a week, for 3 weeks) effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft models. MCE has not independently confirmed the accuracy of these methods. They are for referenc Biological Activity:Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC 50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma

C26H32ClN7O4S

574.09 g/mol

OC1CCN(C2=CC=C(NC3=NC(NC4=CC=CC=C4S(=O)(C(C)C)=O)=C5N=CNC5=N3)C(OC)=C2)CC1.[H]Cl

DMSO : ≥ 20 mg/mL (34.84 mM)