Necrostatin-1has been used to investigate its effect on the regulation of interleukin (IL)-33 expression during liver injury in mice in vivo and in hepatic stellate cells in vitro.It has also been used as an inhibitor of receptor-interacting protein kinase 1 (RIPK1) in experimental studies. Necrostatin-1has been used to investigate its effect on the regulation of interleukin (IL)-33 expression during liver injury in mice in vivo and in hepatic stellate cells in vitro.It has also been used as an inhibitor of receptor-interacting protein kinase 1 (RIPK1) in experimental studies.