硝唑尼特, 丙酮酸铁氧还蛋白氧化还原酶抑制剂

NTZ | 2-​(acetyloxy)​-​N-​(5-​nitro-​2-​thiazolyl)​-benzamide

Nitazoxanide (NSC 697855)

N408847-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

Nitazoxanide是一种广谱驱虫剂 (anthelmintic)，对感染动物和人类的各种蠕虫、原生动物和肠道细菌都具有作用活性。 Nitazoxanide 在无菌培养中抑制 Giardia lamblia 滋养体增殖，IC50 为 2.4 μM。Nitazoxanide可用于寄生虫性 (parasitic) 胃肠炎的研究。Nitazoxanide还具有抗病毒特性。 Nitazoxanide 在小鼠模型中显示出抗日本脑炎病毒 (JEV) 活性。 Information Nitazoxanide (NTZ, NSC 697855) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulatesautophagyand inhibitsmTORC1signaling. In vitro Nitazoxanide reduces parasite growth in cell culture by more than 90% with little evidence of drug-associated cytotoxicity. Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. Nitazoxanide and its metabolite tizoxanide are more active in vitro than metronidazole against G. intestinalis, E. histolytica and T. vaginalis. Nitazoxanide exhibits potent inhibition of both HBV and HCV replication. Nitazoxanide potentiates the effect of subsequent treatment with Nitazoxanide plus IFN, but not Nitazoxanide plus 2\'CmeC, in HCV replicon-containing cells. Nitazoxanide induces reductions in several HBV proteins (HBsAg, HBeAg, HBcAg) produced by 2.2.15 cells, but does not affect HBV RNA transcription. Nitazoxanide exhibits IC50, and IC90 values of 0.017 and 0.776 mg/mL respectively, against E. histolytica, 0.004 and 0.067 mg/mL against G. intestinalis, and 0.034 and 2.046 mg/mL against T. vaginalis. Nitazoxanide is more toxic than metronidazole and albendazole against E. histolytica. In vivo Nitazoxanide is partially effective at reducing the parasite burden in a gnotobiotic piglet diarrhea model when given orally for 11 days at 250 mg/kg/day but not at 125 mg/kg/day. Nitazoxanide induces a drug-related diarrhea in piglets that might have influenced its therapeutic efficacy. Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥99%

Nitazoxanide（NTZ，NSC 697855）是一种合成的硝基噻唑水杨酰胺衍生物，也是一种抗原虫药（对犬流感病毒的 IC50 值为 0.17 至 0.21 μM）。Nitazoxanide 可调节自噬和抑制 mTORC1 信号传导。

55981-09-4(DMSO)

C12H9N3O5S

307.28 g/mol

CC(=O)OC1=C(C=CC=C1)C(=O)NC2=NC=C(S2)[N+]([O-])=O

Solubility (25°C) In vitro DMSO: 57 mg/mL (201.17 mM); Ethanol: 4 mg/mL (14.11 mM); Water: Insoluble;

1.398

1225475

抑制剂

丙酮酸铁氧还蛋白氧化还原酶抑制剂

62

201.77

<1

4

1

5