NMDAR/TRPM4-IN-2 free base

NMDAR/TRPM4-IN-2 游离碱

MS-23619 | 1353979-43-7 | HY-139192A | AM94336 | N'-[(3-bromophenyl)methyl]-N'-ethylethane-1,2-diamine | AKOS026821827 | SCHEMBL21902831 | (2-AMINOETHYL)[(3-BROMOPHENYL)METHYL]ETHYLAMINE | F73436 | N1-(3-bromobenzyl)-N1-ethylethane-1,2-diamine | N*1*-(3-B

NMDAR/TRPM4-IN-2 free base

N647282-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC 50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss. In Vitro NMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner. NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Liquid

NMDAR/TRPM4-IN-2 游离碱（化合物 8）是一种强效的 NMDAR/TRPM4 相互作用界面抑制剂。NMDAR/TRPM4-IN-2 游离碱具有神经保护活性。NMDAR/TRPM4-IN-2 游离碱可防止 NMDA 诱导的海马细胞死亡和线粒体功能障碍。

1353979-43-7

C11H17BrN2

257.175 g/mol

66568274

CCN(CCN)CC1=CC(=CC=C1)Br

N'-[(3-bromophenyl)methyl]-N'-ethylethane-1,2-diamine

1S/C11H17BrN2/c1-2-14(7-6-13)9-10-4-3-5-11(12)8-10/h3-5,8H,2,6-7,9,13H2,1H3

XSMDMHAMGOGFLG-UHFFFAOYSA-N

CCN(CCN)CC1=CC(=CC=C1)Br

66568274

DMSO : 100 mg/mL (388.85 mM; Need ultrasonic)

1

2

5

256.058 Da

256.058 Da

29.300 Ų

14

0

152.000

0

1

1.900