NH-3

小分子

NH-3

N648043-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC 50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment In Vivo NH3 (46.2-27,700 nmol/kg/day; 7 days) decreases heart rate modestly starting at 46.2 nmol/kg/day, but the effect was lost at >2920 nmol/kg/day. NH3 has no effect on the cholesterol-lowering action of 46.2 nmol/kg/day T3, but it inhibits the tachycardic and TSH suppressant effects up to the 924 nmol/kg/day dose. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 55 nM (THR)

NH-3 是一种口服活性、可逆的甲状腺激素受体（THR）拮抗剂，其 IC 50 为 55 nM。NH-3 是选择性甲状腺激素受体 GC-1 的衍生物，可抑制甲状腺激素与其受体的结合，并抑制辅助因子的招募[1]。

447415-26-1

C28H27NO6

473.52 g/mol

10027822

CC1=CC(=CC(=C1CC2=CC(=C(C(=C2)C(C)C)O)C#CC3=CC=C(C=C3)[N+](=O)[O-])C)OCC(=O)O

CC1=CC(=CC(=C1CC2=CC(=C(C(=C2)C(C)C)O)C#CC3=CC=C(C=C3)[N+](=O)[O-])C)OCC(=O)O

10027822

DMSO : 100 mg/mL (211.18 mM; Need ultrasonic)

2

6

8

473.184 Da

473.184 Da

113.000 Ų

35

0

774

0

1

6.8