NCGC00029283

小分子

NCGC00029283

N648485-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC 50 s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively. In Vitro NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: U2-OS cells Concentration: 1 μM, 10 μM, 100 μM Incubation Time: 24 h, 48 h, 72 h Result: Showed a reduction in U2-OS cell proliferation. Form:Solid

NCGC00029283 是一种维尔纳综合征螺旋酶核酸酶（WRN）螺旋酶抑制剂，对 WRN、BLM 和 FANCJ 螺旋酶的 IC 50 s 分别为 2.3 μM、12.5 μM 和 3.4 μM。

714240-31-0

C18H12FN3O3

337.30 g/mol

651756

COC1=CC2=C(C=C1)NC(=O)C(=C2)C3=NOC(=N3)C4=CC=C(C=C4)F

3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy-1H-quinolin-2-one

1S/C18H12FN3O3/c1-24-13-6-7-15-11(8-13)9-14(17(23)20-15)16-21-18(25-22-16)10-2-4-12(19)5-3-10/h2-9H,1H3,(H,20,23)

FJQADEHMIMENRE-UHFFFAOYSA-N

COC1=CC2=C(C=C1)NC(=O)C(=C2)C3=NOC(=N3)C4=CC=C(C=C4)F

651756

DMSO : 6.94 mg/mL (20.58 mM; ultrasonic and warming and heat to 60°C)

1

6

3

337.086 Da

337.086 Da

77.300 Ų

25

0

536.000

0

1

3.000