N-Desmethyl-Apalutamide

N-去甲基阿帕鲁胺

ARN000308 | ARN-000308 | 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzamide | 4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide

N-Desmethyl-Apalutamide

N649822-5mg

5mg

≥97%

-20°C储存

超低温冰袋运输

N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration Form:Solid IC50& Target:CYP3A4 and CYP2B6, ,\nAndrogen receptor

N-去甲基阿帕鲁胺是阿帕鲁胺的活性代谢物。N-去甲基阿帕鲁胺是一种效力较弱的雄激素受体拮抗剂，其活性仅为阿帕鲁胺的三分之一。N-去甲基阿帕鲁他胺的形成介导了阿帕鲁他胺的活性。

1332391-11-3

C20H13F4N5O2S

463.41 g/mol

86683490

C1CC2(C1)C(=O)N(C(=S)N2C3=CC(=C(C=C3)C(=O)N)F)C4=CC(=C(N=C4)C#N)C(F)(F)F

4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide

1S/C20H13F4N5O2S/c21-14-7-10(2-3-12(14)16(26)30)29-18(32)28(17(31)19(29)4-1-5-19)11-6-13(20(22,23)24)15(8-25)27-9-11/h2-3,6-7,9H,1,4-5H2,(H2,26,30)

BAANHOAPFBHUDX-UHFFFAOYSA-N

C1CC2(C1)C(=O)N(C(=S)N2C3=CC(=C(C=C3)C(=O)N)F)C4=CC(=C(N=C4)C#N)C(F)(F)F

86683490

1332391-11-3

DMSO : 100 mg/mL (215.79 mM; Need ultrasonic)

1

9

3

463.073 Da

463.073 Da

135.000 Ų

32

0

870

0

1

2.6