NMDAR/TRPM4-IN-2 free base

NMDAR/TRPM4-IN-2 游离碱

NMDAR/TRPM4-IN-2 free base

N654961-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC 50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss. In Vitro NMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner. NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NMDAR/TRPM4-IN-2 游离碱（化合物 8）是一种强效的 NMDAR/TRPM4 相互作用界面抑制剂。NMDAR/TRPM4-IN-2 游离碱具有神经保护活性。NMDAR/TRPM4-IN-2 游离碱可防止 NMDA 诱导的海马细胞死亡和线粒体功能障碍。

1353979-43-7(DMSO)

C11H17BrN2

257.175 g/mol

CCN(CCN)CC1=CC(=CC=C1)Br