N-Desmethyl-Apalutamide

N-去甲基阿帕鲁胺

N-Desmethyl-Apalutamide

N656012-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration IC50& Target:CYP3A4 and CYP2B6, ,\nAndrogen receptor

N-去甲基阿帕鲁胺是阿帕鲁胺的活性代谢物。N-去甲基阿帕鲁胺是一种效力较弱的雄激素受体拮抗剂，其活性仅为阿帕鲁胺的三分之一。N-去甲基阿帕鲁他胺的形成介导了阿帕鲁他胺的活性。

1332391-11-3(DMSO)

C20H13F4N5O2S

463.41 g/mol

C1CC2(C1)C(=O)N(C(=S)N2C3=CC(=C(C=C3)C(=O)N)F)C4=CC(=C(N=C4)C#N)C(F)(F)F