NG-497

NG-497

N656080-1ml

1ml

10mM in DMSO

避光,干燥,-80℃储存

超低温冰袋运输

NG-497 is a selective human adipose triglyceride lipase ( ATGL ) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. NG-497 has potential value for tumor research. In Vitro NG-497 selectively inactivates human and nonhuman primate ATGL but not structurally and functionally related lipid hydrolases and abolishes human adipocytes in a dose-dependent and reversible manner Lipolysis. NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NG-497 是一种选择性人脂肪甘油三酯脂酶（ATGL）抑制剂，其靶标是具有酶活性的人 ATGL 蛋白样结构域。NG-497 具有潜在的肿瘤研究价值。

2598242-66-9(DMSO)

C18H21NO4

315.36 g/mol

O=C(C1=CC(OC)=CC(C2=CC=C(OCC)C=C2)=N1)OC(C)C