NecroIr2

死灵I2

NecroIr2

N658812-5mg

5mg

≥98%

2-8°C储存,避光,干燥

冰袋运输

NecroIr2 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin ( HY-17394 )-resistant lung cancer cells (A549R). NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential ( Appearance:Solid IC50& Target:CDK4 RIPK3 RIPK1 In Vitro:NecroIr2 (2 μM; 1-2 d) exerts subcellular distribution over 90% accumulated in mitochondria in non-labelled A549R and CFSE labelled L02 cells. NecroIr2 (1.5 μM and 3 μM; 24 h) results ROS generation increasing and loss of mitochondrial membrane poten Biological Activity:NecroIr2 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin ( HY-17394 )-resistant lung cancer cells (A549R). NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (

C46H30ClIrN6O2-

926.44 g/mol

C1(C2=NC(C=CC=C3)=C3O2)=CC(C4=[N]5C=CC(C6=NC(C=CC=C7)=C7O6)=C4)=[N]([Ir]89([N]%10=CC=CC=C%10C%11=C9C=CC=C%11)5[N]%12=CC=CC=C%12C%13=C8C=CC=C%13)C=C1.[Cl-].[+]

DMSO : 50 mg/mL (53.97 mM; Need ultrasonic)