N-Desethyl Sunitinib hydrochloride

N-去乙基舒尼替尼盐酸盐

N-Desethyl Sunitinib hydrochloride

N659478-5mg

5mg

≥99%

2-8°C储存,干燥

冰袋运输

N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR , PDGFRβ and KIT inhibitor with K i values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively. Appearance:Solid In Vitro:Sunitinib also potently inhibits Kit and FLT-3. Sunitinib is a potent ATP-competitive inhibitor of VEGFR2 (Flk1) and PDGFRβ with K i of 9 nM and 8 nM, respectively, displaying >10-fold higher selectivity for VEGFR2 and PDGFR than FGFR-1, EGFR, Cdk2, In Vivo:Sunitinib (20-80mg/kg/day) exhibits broad and potent dose-dependent anti-tumor activity against a variety of tumor xenograft models including HT-29, A431, Colo205, H-460, SF763T, C6, A375, or MDA-MB-435, consistent with the substantial and selective inhi Biological Activity:N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR , PDGFRβ and KIT inhibitor with K i values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively.

C20H24ClFN4O2

406.88 g/mol

O=C1NC2=CC=C(F)C=C2/C1=C/C3=C(C)C(C(NCCNCC)=O)=C(C)N3.[H]Cl

DMSO : 50 mg/mL (122.89 mM; Need ultrasonic)