N-[（1R,8S,9s）-双环[6.1.0]壬-4-炔-9-甲氧基羰基] -1,8-二氨基-3,6-二氧杂辛烷可用于双环[6.1.0]壬烯（BCN）功能化透明质酸，用于开发具有可调性质的响应性 HA 基物理水凝胶。 胺官能化的环辛炔衍生物。环辛炔可用于应变促进的无铜叠氮化物-炔烃环加成反应。该应变环辛炔将与叠氮官能化化合物或生物分子反应，无需铜催化剂即可产生稳定的三唑键 Amine functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This strained cyclooctyne will react with azide functionalized compounds or biomolecules without the need for a copper catalyst to result in a stable triazole linkage. N-[(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyloxycarbonyl]-1,8-diamino-3,6-dioxaoctane may be used to functionalize hyaluronic acid with bicyclo[6.1.0]nonyne (BCN) for the development of responsive HA-based physical hydrogels with tunable properties