一种天然止痛药，可分泌到人的唾液中。卵磷脂 对脑啡肽失活的表肽酶人类NEP（hNEP）和人类AP-N（hAP-N）表现出双重抑制作用。作为镇痛药，阿片吡啶比鸦片吗啡强6倍。卵磷脂 与大鼠唾液酸蛋白肽密切相关，后者是疼痛感知的抑制剂，并通过增强内源性微和δ阿片受体依赖性脑啡肽通路而起作用。在大鼠研究中，卵磷脂 抑制了化学诱导的炎症和急性身体疼痛的疼痛感。在这两种情况下，1 mg / kg的给药剂量均具有与3-6 mg / kg吗啡相同的止痛能力。 A natural analgesic that is secreted into human saliva. Opiorphin demonstrates dual-inhibitory potency on the enkephalin-inactivating ectopeptidases human NEP (hNEP) and human AP-N (hAP-N). As an analgesic, Opiorphin is 6 times stronger than the opiate morphine. Opiorphin is closely related to the rat sialorphin peptide, which is an inhibitor of pain perception and acts by potentiating endogenous micro- and δ-opioid receptor-dependent enkephalinergic pathways. In rat studies, Opiorphin suppressed pain sensation for both chemical-induced inflammation and acute physical pain. In both cases, the administered dose of 1 mg/kg provided the same painkilling power as 3-6 mg/kg of morphine.