ORM-15341

未知

GMBPVBVTPBWIKC-NSHDSACASA-N | 9EPS75QMTL | 1297537-33-7 | HY-19337 | XBC53733 | NCGC00485475-01 | A920206 | Q27272459 | AC-36362 | MS-26697 | ZB1629 | EX-A3189 | AKOS030526386 | 3-acetyl-N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-1H-py

ORM-15341

O646660-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.IC50 value: 38 nMTarget: androgen receptor in vitro: In competitive AR binding assays, the inhibition constant (Ki) values of ORM-15341 was 8 nM. ORM-15341 functions as a full antagonist for all tested mutant ARs , with IC50 of 25, 51, 700, and 1160 nM for wtAR, AR(F876L), AR(T877A), and AR(W741L). Form:Solid

在稳定表达全长 hAR 和雄激素反应型荧光素酶报告基因构建体的 AR-HEK293 细胞中进行的转录激活试验表明，ORM-15341 是一种强效的人 AR（hAR）完全拮抗剂，其 IC50 值为 38 nM：38 n

1297537-33-7

C19H17ClN6O2

396.83 g/mol

941-760-1

52919826

C[C@@H](CN1C=CC(=N1)C2=CC(=C(C=C2)C#N)Cl)NC(=O)C3=CC(=NN3)C(=O)C

3-acetyl-N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-1H-pyrazole-5-carboxamide

1S/C19H17ClN6O2/c1-11(22-19(28)18-8-17(12(2)27)23-24-18)10-26-6-5-16(25-26)13-3-4-14(9-21)15(20)7-13/h3-8,11H,10H2,1-2H3,(H,22,28)(H,23,24)/t11-/m0/s1

GMBPVBVTPBWIKC-NSHDSACASA-N

CC(CN1C=CC(=N1)C2=CC(=C(C=C2)C#N)Cl)NC(=O)C3=CC(=NN3)C(=O)C

52919826

1297537-33-7

DMSO : 100 mg/mL (252.00 mM; Need ultrasonic)

2

5

6

396.11 Da

396.11 Da

116.000 Ų

28

0

637

0

1

2.2