Opiranserin (VVZ-149) hydrochloride, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A) , with IC 50 s of 0.86 and 1.3 μM, respectively. Opiranserin hydrochloride shows antagonistic activity on rP2X3 (IC 50 =0.87 μM). Opiranserin hydrochloride is development as an injectable agent for the treatment of postoperative pain Form:Solid IC50& Target:GlyT2 0.86 μM (IC 50 ) P2X3 Receptor rP2X3 0.87 μM (IC 50 ) 5-HT 2A Receptor 1.3 μM (IC 50 )