ON-013100

小分子

MS-26627 | Q27281151 | ON013100 | ON-013100 | GHPUSRLWNSTQIK-BQYQJAHWSA-N | HY-112822 | Phenol, 2-methoxy-5-(((2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)- | UNII-J3I19I491A | (E)-2-methoxy-5-((2,4,6-trimethoxystyrylsulfonyl)methyl)phenol | Phenol,

ON-013100

O646809-5mg

5mg

≥98%

-20°C储存

超低温冰袋运输

ON-013100, an antineoplastic agent, acts a mitotic inhibitor that could inhibit Cyclin D1 expression. In Vitro ON-013100 induces apoptosis, and has activity against most human cancer cell lines in vitro . ON013100 significantly alters the cell cycle profile, dramatically increasing the number of cells in G2/M phase. Treatment of the cells with even 0.1 μM of ON013100 results in an arrest of the G2/M phase of the cell cycle. ON 013100 inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at a nanomolar concentration (ON 013100 GI 50 =6.7-11.2 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Cdk4/cyclin D1

ON-013100 是一种抗肿瘤药物，是一种有丝分裂抑制剂，可抑制 Cyclin D1 的表达。

865783-95-5

C19H22O7S

394.44 g/mol

11269418

COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)O

2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenol

1S/C19H22O7S/c1-23-14-10-18(25-3)15(19(11-14)26-4)7-8-27(21,22)12-13-5-6-17(24-2)16(20)9-13/h5-11,20H,12H2,1-4H3/b8-7+

GHPUSRLWNSTQIK-BQYQJAHWSA-N

COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)O

11269418

865783-95-5

(E)-2,4,6-trimethoxystyryl-3- hydroxy-4-methoxybenzyl sulfone;ON 013100;ON013100

DMSO : 25 mg/mL (63.38 mM; Need ultrasonic)

1

7

8

394.109 Da

394.109 Da

99.700 Ų

27

0

557.000

0

1

2.600