Org41841

小分子

组织41841

cid_9887381 | 5-amino-N-tert-butyl-4-(3-methoxyphenyl)-2-methylsulfanylthieno[2,3-d]pyrimidine-6-carboxamide | CHEBI:93615 | tert-Butyl 5-amino-2-methylthio-4-(3-methoxyphenyl)-thieno[2,3-d]pyrimidine-6-carboxamide | DVSFSADBOJYPGF-UHFFFAOYSA-N | HY-10027

Org41841

O648726-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor ( LHCGR ) and thyroid-stimulating hormone receptor ( TSHR ) with EC 50 s of 0.2 and 7.7 μM, respectively. In Vitro Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC 50 s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC 50 of 800 nM. M9 responds to Org41841 with an improved EC 50 of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EC50: 0.2 μM (LHCGR), 7.7 μM (TSHR)

Org41841 是促黄体生成素/绒毛膜促性腺激素受体（LHCGR）和促甲状腺激素受体（TSHR）的部分激动剂，其 EC 50 s 分别为 0.2 和 7.7 μM。

301847-37-0

C19H22N4O2S2

402.53 g/mol

9887381

CC(C)(C)NC(=O)C1=C(C2=C(N=C(N=C2S1)SC)C3=CC(=CC=C3)OC)N

5-amino-N-tert-butyl-4-(3-methoxyphenyl)-2-methylsulfanylthieno[2,3-d]pyrimidine-6-carboxamide

1S/C19H22N4O2S2/c1-19(2,3)23-16(24)15-13(20)12-14(10-7-6-8-11(9-10)25-4)21-18(26-5)22-17(12)27-15/h6-9H,20H2,1-5H3,(H,23,24)

DVSFSADBOJYPGF-UHFFFAOYSA-N

CC(C)(C)NC(=O)C1=C(C2=C(N=C(N=C2S1)SC)C3=CC(=CC=C3)OC)N

9887381

301847-37-0

Org 41841;Org-41841;Org41841

DMSO : 100 mg/mL (248.43 mM; Need ultrasonic)

2

7

5

402.118 Da

402.118 Da

144.000 Ų

27

0

530

0

1

4.5